review of uterine cancers

Review of uterine neoplasms to evaluate the frequencies of different morphological types of uterine cancers and to compare the results with different age groups and the findings of other workers. Observational and comparative study. This study was conducted at the Department of Pathology, Basic Medical Science Institute, JPMC, Karachi from January 2002 to December 2011. A total of 927 cases of neoplastic lesions of the uterine corpus, received over a period of 10 years at the department of Pathology, Basic Medical Science Institute, JPMC, Karachi were reviewed. A total of 98 [9.45%] were uterine cancers including 82 [83.67%] carcinomas and 16 [16.32%] sarcomas. Adenocarcinoma was the commonest finding [66/98], followed by squamous cell carcinoma [10/98] and endometrial stromal sarcomas [7/98]. The mean age of uterine carcinomas was 51.48 years and of sarcomas was 41.87 years. Grade III Adenocarcinoma presented at relatively late ages [mean age 60.71 years] than grade II [mean age 56.37 years] and grade I [mean age 47.02 years]. Sarcomas were found to be of relatively high frequency in our study [16.32%]. Leiomyosarcoma [LMS] and endometrial stromal sarcoma [ESS] tend to occur at younger age than carcinosarcomas. Mean age of uterine carcinoma was found to be 51.48 years and of sarcomas 41.87 years. Grade I adenocarcinoma is more common in younger age groups than grade II and III adenocarcinoma. Finally the LMS and ESS are more frequent than malignant mixed mesodermal tumors [MMMT]

Seroprevalence of toxoplasmosis [by detecting IgM antibiodies] in women with repeated abortions

To determine seroprevalence of Toxoplasmosis in women with repeated abortions in our local population. Prospective Cross-sectional study. This study was conducted in the Department of Microbiology Basic Medical Sciences Institute [BMSI] Jinnah Postgraduate Medical Centre [JPMC] Karachi from April 2006 to May 2008. Sera from 130 pregnant and post-aborted women with history of repeated abortions [group A] and 50 pregnant women with no history of abortion [group B - as controls] were analyzed for Toxoplasma IgM antibodies by ELISA technique to see the prevalence of toxoplasmosis. 24% of women of group A and 14% of women of group B were seropositive for toxoplasma IgM antibodies. Most of the cases with toxoplasmosis have had their abortions in the first trimester. Gradual increase in Toxoplasma antibody positivity with increasing gravida was observed. Women with negative serological status are at risk of acquiring a primary infection during pregnancy, hence education regarding preventive measures should be provided to them and every pregnant woman may be advised for Toxoplasma IgM antibodies investigation